In Vitro Fertilisation IVF

Overview

Indications

Process

Complications

Overview

‘Test tube baby’ is a non-medical term for babies that are conceived using the artificial reproductive technique of in-vitro fertilization (IVF). Here, the eggs are fertilized outside the human body and then implanted in the uterus. 

In Vitro Fertilisation IVF Indications

IVF is a relatively expensive procedure and is opted for when there are no other treatment options. IVF may be recommended for individuals with the following conditions:


  • Low sperm count
  • Low sperm mobility
  • Endometriosis
  • Problems related to the uterus or fallopian tubes
  • Inability of the sperm to penetrate or survive the cervical mucus
  • Issues related to ovulation 
  • Individuals planning for surrogacy 

In Vitro Fertilisation IVF Process

To improve the chances of a success, fertility drugs are administered to induce multiple follicle productions. Careful monitoring using ultrasound and hormone testing is performed, and the decision of the discontinuation of drugs and egg retrieval is taken by doctors. Egg retrieval takes place using an ultrasound-guided needle. Fluid from ovaries is carefully withdrawn and examined for the presence of eggs. Retrieved eggs are then fertilized with the sperms from the partner or donor. The resulting embryos are then cultured and monitored for 3 to 5 days. Then the embryo is transferred into the uterus of the female for implantation. In a few cases, there may be excess embryos even after the transfer. The final decision on the fate of these excess embryos lies with the couple. An alternative of cryopreservation also exists, and the embryos can be preserved for future use or even donated to other couples looking for IVF.

In Vitro Fertilisation IVF Complications

Multiple births - Risk of multiple childbirths increases if more than one embryo is implanted in your uterus using IVF technique. 


Premature delivery and low birth weight


Miscarriage - There are about 15 to 25% chances of miscarriage in a pregnancy whether you have naturally conceived or with of IVF.


Ovarian hyper-stimulation syndrome - is a medical condition affecting the ovaries of women who take fertility medications to stimulate egg growth or to induce ovulation.


Egg retrieval procedure complications - An aspirating needle used to collect eggs from ovaries could possibly cause bleeding, infection or damage to the bowel, bladder or a blood vessel. 


Mental Stress - Dealing with infertility and choosing IVF is physically,emotionally and financially stressful for the family. 

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Frequently Asked Questions

  • What is Endometriosis?

    Endometriosis is a painful disorder affecting the female reproductive system. Essentially, in endometriosis, the tissue that lines the uterine cavity i.e. the endometrium is displaced outside the cavity and latches onto another organ.The displaced tissue adheres to this new surface and irritates the surrounding tissues forming cysts called endometriomas. Continuous irritation leads to the formation of scars and adhesions leading to pelvic discomfort. 

  • Can I become pregnant if I have endometriosis?

    Yes, you can become pregnant even if you are suffering from endometriosis. The chances of conception are directly proportional to the severity of endometriosis. In minimal to mild cases, the chances are good, but it worsens as endometriosis becomes severe.

  • If I become pregnant, will endometriosis affect my pregnancy?

    No, endometriosis does not affect your pregnancy. 

  • Can pregnancy cure endometriosis?

    It is a general tendency to believe that pregnancy may cure endometriosis as you do not menstruate during pregnancy. However, the fact is that pregnancy does not cure endometriosis. During pregnancy, the symptoms remain suppressed due to the hormonal changes in the body. Once the baby is delivered and you start menstruating, the symptoms return.

  • Will artificial reproductive techniques (ART) help me to conceive if I have endometriosis?

    Yes, ARTs like In vitro fertilization (IVF) and other techniques are a good option for those suffering from endometriosis and can't conceive.


  • Will I surely get pregnant with IVF?

    No, not all procedures result in a successful pregnancy. However, success rate improves with each cycle, up to 3 cycles.

  • What is Recurrent Implantation Failure (RIF)?

    If the couple fails to conceive after 3 IVF cycles, with at least 1-2 healthy embryos being transferred every time, it is termed as Recurrent Implantation Failure (RIF).

  • Why IVF fails?
    The following can be the causes for IVF failure:-
    • Ovarian reserve and quality of eggs drastically reduce with increasing age.
    • Uterine abnormalities that include anatomical malformations, fibroids, and polyps.
    • Poor health of the uterine lining.
    • Decreased blood supply to the uterus due to a condition called thrombophilia, where blood clots block uterine blood vessels.
    • Autoimmune causes such as thyroid autoimmunity and the presence of antiphospholipid antibody, lupus anticoagulant (LAC), anticardiolipin antibody (ACA), and antinuclear antibody (ANA).
    • Poor quality of sperms.
    • Genetic abnormalities in the embryo.
    • An inability of the embryo to hatch and implant.
    • Ovarian hyperstimulation syndrome (OHSS) caused by drugs given during IVF.